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AZD-2281 10 mg



(Olaparib; KU0059436; KU-0059436; 4-[[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluoro-phenyl]methyl]-2H-phthalazin-1-one)

Purity > 99.0 %

  CAS Number:    937799-91-2
  Chemical Formula:    C24H23FN4O3
  Molecular Weight:    435.08 g/mol


Highly potent, oral and selective inhibitor of poly(ADP-ribose) polymerase (PARP); with IC50 = 5nM (PARP-1) and 1 nM (PARP-2). It blocks enzymes that repair DNA damage caused by cancer treatments such as radiation and drugs.

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Celebrity Endorsements

Do, et. al. Molecular pathways: Targeting PARP in cancer treatment Clin Cancer Res; 19(5); 977–84.

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