Isoniazid

Isoniazid is an organic compound that is effectively against tuberculosis and it is always used in combination with other antituberculosis medicines. Antibiotic for treatment of Mycobacterium tuberculosis.

Isoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme called KatG. KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase.

Toxicity: LD₅₀ in mice (mg/kg): 151 i.p., 149 i.v. (Jenney, Pfeiffer).

Appearance: White solid powder

Store: 2-8°C

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