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Isoniazid
| CAS Number: |
54-85-3
|
| Chemical Formula: |
C6H7N3O
|
| Molecular Weight: |
137.14 g/mol
|
Isoniazid is an organic compound that is effectively against tuberculosis and it is always used in combination with other antituberculosis medicines. Antibiotic for treatment of Mycobacterium tuberculosis.
Isoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme called KatG. KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase.
Toxicity: LD50 in mice (mg/kg): 151 i.p., 149 i.v. (Jenney, Pfeiffer).
Appearance: White solid powder
Store: 2-8°C
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| Alfa Aesar | A10583-22 |
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| TCI America | I0138-25G |
| TCI America | I0138-500G |
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