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Anti-MAP Kinase, Activated Monoclonal 100ug

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Anti-MAP Kinase, Activated Monoclonal

Clone IL-13
Size  100μg/vial
Form lyophilized
Ig type mouse IgG1
Immunogen A synthetic peptide containing 11 amino acids, form of ERK-HTGFLTpEYpVAT.
  Corresponding to the phosphorylated activation loop conjugated to KLH.
Application WB; IHC-P; ICC
Cross Reactivity Human, mouse, rat, yeast.
Reconstitution 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used.  
  The antibody concentration will be 100μg/ml.
Storage At -20˚C for one year. After reconstitution, at 4˚C for one month. 
             It can also be aliquotted and stored frozen at -20˚C for a longer time. 
  Avoid repeated freezing and thawing.

In mammalian cells, a variety of extracellular stimuli generate intracellular signals that converge on a limited number of so-called mitogen-activated protein (MAP) kinase pathways. The central core of each MAP kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. Mek1/2 MAPK kinases are essential for mammalian development, homeostasis, and Raf-induced hyperplasia. Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome.

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