Enramycin B

Purity > 85.0%

Enramycin (also known as Enduracidin and Enradin) is a polypeptide antibiotic produced by Streptomyces fungicidus and developed as a food additive in Japan. Enramycin is slightly soluble in water and freely soluble in dilute HCl solution. Enramycin is composed of two different compounds: enramycin A and enramycin B.

Enramycin acts as a MurG inhibitor involved peptidoglycan synthesis in gram positive bacteria. MurG catalyzes the transglycosylation reaction in the last step of peptidoglycan biosynthesis. Inhibition of this step greatly compromises cell wall integrity leading to cell death by lysis.

Enramycin has a strong antibacterial activity against Gram-positive bacteria and inhibits development of major gut flora pathogens.  Resistance or cross-resistance with existing antibiotics has rarely been observed.