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APO 8 1 g



(Dimethyloctylphosphine oxide; Octyl dimethyl-phosphine oxide)

Purity > 98 %

  CAS Number:
  Chemical Formula:
  Molecular Weight:
  190.1 g/mol


APO 8 is a non ionic alkyl phosphine oxide detergent.

  • Novel non ionic detergent useful in two phase separation and purification of proteins
  • APO 8 is commonly used detergent in protein crystallization and maybe referred to as dimethyloctylphosphine oxide or dimethyl octylphosphine oxide
  • APO 8 gives excellent yields of high quality DNA
  • Purification of plasmid DNA using APO 8 does not require the use of chloroform / phenol or resins

Celebrity Endorsements

Cudney, B; Patel, S; Weisgraber, K; Yvonne, N; McPherson, A; Screening and Optimization Strategies for Macromolecular Crystal Growth. Acta Cryst. (1994). D50, 414-423.

Examines a number of factors that influence protein crystallization including precipitating and crosslinking agents. In addition, more than 30 detergents were explored for their ability to prevent sample aggregation and influence crystal growth.

Vergis, J.M.; Purdya, M.D.; Wiener, M.C. A High-Throughput Differential Filtration Assay to Screen and Select Detergents for Membrane Proteins. Analytical Biochemistry. (2010), Vol. 407, Issue 1, 1-11.

Paper discusses the development of an assay that characterizes the stability and size of membrane proteins exchanged into a panel of 94 commercially available and chemically diverse detergents.

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