Clone | Spe 1/2 |
Size | 100μg/vial |
Form | lyophilized |
Ig type | mouse IgG1 |
Immunogen | Human erythrocyte spectrin. |
Application | WB |
Cross Reactivity | Human. |
Reconstitution | 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, |
the antibody concentration will be 100μg/ml. | |
Storage | At -20˚C for one year. After reconstitution, at 4˚C for one month. |
It can also be aliquotted and stored frozen at -20˚C for a longer time. | |
Avoid repeated freezing and thawing. | |
Spectrin, the predominant component of the membrane skeleton of the red cell, is essential in determining the properties of the membrane including its shape and deformability. It consists of 2 nonidentical subunits, alpha and beta. Spectrin is present in the red cell membrane in a tetrameric or possibly higher polymeric form through head-to-head self-association of heterodimers that are linked by actin polymers and protein 4.1 to form a 2-dimensional network. Non-erythroid spectrin gene is mapped to human chromosome 2. Spectrin mutations cause spinocerebellar ataxia type 5. |