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Categories
PD-0325901
Purity > 99.0 %
| CAS: |
391210-10-9
|
| Chemical Formula: |
C16H14F3IN2O4
|
| Molecular Weight: |
482.19 g/mol
|
An orally bioavailable, synthetic organic molecule targeting mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. MEK inhibitor PD325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation.
The dual specific threonine/tyrosine kinase MEK is a key component of the AS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors.
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