IL6, Human

(Recombinant Human Interleukin 6, IL-6 Protein)

Purity: >95% by SDS-PAGE

Source: Escherichia coli

Cytokines of the IL6/GCSF/MGF family are glycoproteins of about 170 to 180 amino acid residues that contain four conserved cysteine residues involved in two disulphide bonds. They have a compact, globular fold (similar to other interleukins), stabilized by the 2 disulphide bonds. One half of the structure is dominated by a 4 alpha-helix bundle with a left-handed twist: the helices are anti-parallel, with 2 overhand connections, which fall into a 2-stranded anti-parallel beta-sheet. The fourth alpha helix is important to the biological activity of the molecule. Interleukin-6 (IL-6) is an important proinflammatory and immunoregulatory cytokine expressed by various cells. Interleukin-6 has been shown to inhibit the growth of early stage and to promote the proliferation of advanced stage melanoma cells in vitro.

rHuIL6 General Information
Description:
Recombinant Human IL6 Protein, made in E. Coli, with the following amino acid sequence: Val30-Met212 of Human il-6 (Uniprot# P05231).

Reconstitution:
Reconstitute lyophilized powder with PBS to no less than 100 µg/ml, which can be further diluted in other desired aqueous solutions.

Storage:
Lyophilized form is stable at room temperature for 3 weeks. Keep desiccated at below -18°C for long term storage. After reconstituted, store at 4°C for 2-7 days or at below -18°C for up to 3 months. Avoid repeated freeze/thaw cycles.

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