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Ceftriaxone sodium 250 mg


Ceftriaxone sodium, USP

  CAS Number:
  Chemical Formula:
  C18H16N8Na2O7S3 3.5 H2O
  Molecular Weight:
  661.60 g/mol


Ceftriaxone sodium is third generation cephalosporin with a broad spectrum including many gram-positive and gram-negative bacteria. It is very similar in action to Cefotaxime. Ceftriaxone is often used (in combination, but not direct, with macrolide and/or aminoglycoside antibiotics) for the treatment of community-acquired or mild to moderate health care-associated pneumonia. It is also a choice drug for treatment of bacterial meningitis.

Ceftriaxone works by inhibiting the mucopeptide synthesis in the bacterial cell wall. The beta-lactam moiety of Ceftriaxone binds to carboxypeptidases, endopeptidases, and transpeptidases in the bacterial cytoplasmic membrane. These enzymes are involved in cell-wall synthesis and cell division. By binding to these enzymes, Ceftriaxone results in the formation of of defective cell walls and cell death.

The syn-configuration of the methoxyimino moiety confers stability to β-lactamase enzymes produced by many gram-negative bacteria. Such stability to β-lactamases increases the activity of ceftriaxone against otherwise resistant gram-negative bacteria. In place of the easily hydrolysed acetyl group of cefotaxime, ceftriaxone has a metabolically stable thiotriazinedione moiety.

Store 2-8°C in an airtight container protected from light. If the substance is sterile, store in a sterile, airtight, tamper-proof container.


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Comparable Items:

  TCI America    C2226-5G
  TCI America    C2226-25G
  Toronto Research Chemicals    C2450001G
  US Pharmacopeia    1098184

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