Ceftiofur Sodium

(Sodium (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(2-furoylsulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate)

Purity > 95.0%

Ceftiofur is a third generation cephalosporin. Like other cephalosporins, Ceftiofur acts by inhibiting the cross-linkage of peptidoglycans in non-resistant cell walls and triggers the activation of damaging autolysins.  Ceftiofur is effective against pathogen Pasteurella, Actinobacillus and Escherichia coli. Ceftiofur is a good substrate of  the universal efflux pump AcrA/B.

β-Lactam antibiotics work by inhibiting the formation of peptidoglycan cross-links in the bacterial cell wall. The β- lactam moiety (functional group) of penicillin binds to the enzyme (DD-transpeptidase) that links the peptidoglycan molecules in bacteria, which weakens the cell wall of the bacterium. In addition, the build-up of peptidoglycan precursors triggers the activation of bacterial cell wall hydrolases and autolysins, which further digest the bacteria's existing peptidoglycan.

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