Bafilomycin A1

Purity > 98.0%

Bafilomycin A1 is a macrolide antibiotic isolated and derived from the fermentation of Streptomyces gniseus. Not only is it very potent, but it has proved to be very selective as an inhibitor of vacuolar Type H+- ATPase. For this reason, it is valuable because of it's ability to distinguish among the different types of ATPases. Bifilomycin A1 can also block lysosomal cholesterol trafficking in macrophages and can interfere with pH regulation in brain cells.

Macrolide antibiotics are bacteriostatic antibiotics with broad spectrum capabilities against gram-positive bacteria. There are four of these macrolide antibiotics in use in the United States today, and they have been well tolerated. They include erythromycin, clarithromycin, azithromycin and telithromycin. Two of these drugs, clarithromycin and azithromycin, are also useful against gram-negative bacteria. It is soluble in ethanol, methanol and DMSO, and is light-sensitive, especially while in solution. It should be stored at below 20 degrees C.

The toxicological properties of this drug have not been fully studied. It is to be used for research purposes only and is not for human or drug use. Do not inhale dust or aerosol spray. Do not get product on the skin. Wear protective clothing and protective eyewear. This product is irritating to the eyes, skin ands respiratory system.

The particular properties of Bifilomycin, and it's ability to specifically inhibit vacuolar type H+-ATPase in animal, plant and bacterial organisms, it is used to differentiate the many types of ATPases, and this also allows it to work at preventing recalcification of synaptic vesicles once they have gone through exocytosis. Bifilomycin A1 is antimicrobial, antifungal, antineoplastic and immunosuppressive. Studies have also found the drug is useful in decreasing multi-drug resistance as well as being effective as an antimalarial when used against P. falciperum.

Addiitionally, studies are now under way assessing it's antiosteoporotic properties in treating bone lytic disorders. But Bifilomycin is most commonly used in demonstrating the need for lowered osomal pH in viral coating. Without a doubt, the antineoplastic properties of this drug are proving to be rewarding to researchers. The drug has been used to inhibit the growth of Capan-1 human pancreatic tumor cells, as well as PC12 cells through apoptosis. Because Bifilomycin can inhibit V-ATPase, this leads to an increase in pH and a corresponding decrease in glycolysis. In effect, this leads to a reduction in tumor cell growth.

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