Clone | IMD-89 |
Size | 100μg/vial |
Form | lyophilized |
Ig type | mouse IgG1 |
Immunogen | Recombinant human Smad4 (DPC4). |
Application | WB; ICC |
Cross Reactivity | Human. |
Reconstitution | 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used. |
The antibody concentration will be 100μg/ml. | |
Storage | At -20˚C for one year. After reconstitution, at 4˚C for one month. |
It can also be aliquotted and stored frozen at -20˚C for a longer time. | |
Avoid repeated freezing and thawing. | |
SMAD4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by mediating transcriptional activation of target genes. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Mutational inactivation of SMAD4 causes TGF-beta unresponsiveness and gave a basis for understanding the physiologic role of this gene in tumorigenesis. Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases. |