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Anti-Smad4/DPC4 Monoclonal
| Clone | IMD-89 |
| Size | 100μg/vial |
| Form | lyophilized |
| Ig type | mouse IgG1 |
| Immunogen | Recombinant human Smad4 (DPC4). |
| Application | WB; ICC |
| Cross Reactivity | Human. |
| Reconstitution | 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used. |
| The antibody concentration will be 100μg/ml. | |
| Storage | At -20˚C for one year. After reconstitution, at 4˚C for one month. |
| It can also be aliquotted and stored frozen at -20˚C for a longer time. | |
| Avoid repeated freezing and thawing. | |
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SMAD4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by mediating transcriptional activation of target genes. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Mutational inactivation of SMAD4 causes TGF-beta unresponsiveness and gave a basis for understanding the physiologic role of this gene in tumorigenesis. Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases. |
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