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Anti-Smad4/DPC4 Monoclonal 100ug

Price:
$215.00
SKU:
BI-MA1089-100UG
Availability:
Usually Ships within 24 hrs.
Quantity:

Anti-Smad4/DPC4 Monoclonal

Clone IMD-89
Size  100μg/vial
Form lyophilized
Ig type mouse IgG1
Immunogen Recombinant human Smad4 (DPC4).
Application WB; ICC
Cross Reactivity Human.
Reconstitution 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used.  
  The antibody concentration will be 100μg/ml.
Storage At -20˚C for one year. After reconstitution, at 4˚C for one month. 
             It can also be aliquotted and stored frozen at -20˚C for a longer time. 
  Avoid repeated freezing and thawing.
   

SMAD4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by mediating transcriptional activation of target genes. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Mutational inactivation of SMAD4 causes TGF-beta unresponsiveness and gave a basis for understanding the physiologic role of this gene in tumorigenesis. Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases.

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