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Anti-SMAD2/3 Polyclonal
| Size | 100μg/vial |
| Form | Liquid |
| Ig type | Rabbit IgG |
| Immunogen | A synthetic peptide corresponding to the N-terminal of human SMAD2/3, identical to the related mouse and rat sequences. |
| Application | WB,IHC-P,IHC-F |
| Contents | Each vial contains 50% glycerol, 0.9mg NaCl, 0.2mg Na2HPO4. |
| Storage | At -20˚C for one year. After reconstitution, at 4˚C for one month. |
| It can also be aliquotted and stored frozen at -20˚C for a longer time. | |
| Avoid repeated freezing and thawing. | |
|
SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors to the nucleus. Transforming growth factor (TGF)-beta stimulation leads to phosphorylation and activation of Smad2 and Smad3, which form complexes with Smad4 that accumulate in the nucleus and regulate transcription of target genes. Smad2 and Smad3 share highly homology. SMAD2/SMAD3 signal transduction appeared to be important in the regulation of muscle-specific genes. SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors to the nucleus. Smad2 is a 58 kDa member of a family of proteins involved in cell proliferation, differentiation and development.Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development. |
|
|
Concentration |
Tested Species |
Concluded Species |
Antigen Retrieval |
|
|
WB |
0.1-0.5μg/ml |
Hu |
Rat, Ms |
- |
|
IHC-P |
0.5-1μg/ml |
Hu |
Rat, Ms |
By Heat |
|
IHC-F |
0.4-1μg/ml |
Hu |
Rat, Ms |
- |
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