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Anti-PTPN11 Polyclonal 100ug

Price:
$215.00
SKU:
BI-PA1860-100UG
Availability:
Usually Ships within 24 hrs.
Quantity:

Anti-PTPN11 Polyclonal

Size  100μg/vial
Form Lyophilized
Ig type Rabbit IgG
Immunogen A synthetic peptide corresponding to a sequence at the C-terminal of human PTPN11, different from the related rat and mouse sequences by one amino acid.
Application WB
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Storage At -20˚C for one year. After reconstitution, at 4˚C for one month. 
             It can also be aliquotted and stored frozen at -20˚C for a longer time. 
  Avoid repeated freezing and thawing.

PTPN11(Tyrosine-protein phosphatase non-receptor type 11), also known as protein-tyrosine phosphatase 1D (PTP-1D) , protein-tyrosine phosphatase 2C (PTP-2C) , TYROSINE PHOSPHATASE SHP2(SHP2), BPTP3, SH-PTP2, SHP-2, SH-PTP3, is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. The open reading frame consists of 1,779 nucleotides potentially encoding a protein of 593 amino acids with a predicted molecular mass of 68 kD. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.


 

Concentration

Tested Species

Concluded Species

Antigen Retrieval

WB

0.1-0.5μg/ml

Hu, Rat, Ms

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