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Anti-P53 Monoclonal 100ug

Price:
$215.00
SKU:
BI-MA1078-100UG
Availability:
Usually Ships within 24 hrs.
Quantity:

Anti-P53 Monoclonal

Clone IMD-53
Size  100μg/vial
Form lyophilized
Ig type mouse IgG2a
Immunogen Recombinant human wild-type p53 protein.
Application WB; IHC-P; IHC-F; ICC
Cross Reactivity Human.
Reconstitution 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used,
  the antibody concentration will be 100μg/ml.
Storage At -20˚C for one year. After reconstitution, at 4˚C for one month. 
             It can also be aliquotted and stored frozen at -20˚C for a longer time. 
  Avoid repeated freezing and thawing.
   

The p53 tumor antigen is found in increased amounts in a wide variety of transformed cells. The protein is also detectable in many actively proliferating, nontransformed cells, but it is undetectable or present at low levels in resting cells. This protein induces cell cycle arrest or apoptosis in response to sublethal or severe DNA damage, respectively, by differential transcription of target genes and through transcription-independent apoptotic functions. The p53 protein contains 393 amino acids. Human p53 tumour antigen is Locatedto band 17p13. p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis.

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