Size | 100μg/vial |
Form | Lyophilized |
Ig type | Rabbit IgG |
Immunogen | A synthetic peptide corresponding to a sequence in the middle region of human MYD88, different from the related rat and mouse sequences by one amino acid. |
Application | WB,IHC-P |
Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Storage | At -20˚C for one year. After reconstitution, at 4˚C for one month. |
It can also be aliquotted and stored frozen at -20˚C for a longer time. | |
Avoid repeated freezing and thawing. | |
MYD88(MYELOID DIFFERENTIATION PRIMARY RESPONSE GENE 88), is a protein that, in humans, is encoded by the MYD88 gene. MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors (IL1Rs).And it is mapped on 3p22.2. MYD88 encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. Qverexpression of MYD88 caused an increase in the level of transcription from the interleukin-8 promoter. The C-terminal domain of MYD88 has significant sequence similarity to the cytoplasmic domain of IL1RAP.Inhibiting the IL1R-MYD88 pathway in vivo could block the damage from acute inflammation that occurs in response to sterile cell death, and do so in a way that might not compromise tissue repair or host defense against pathogens. |
Concentration |
Tested Species |
Concluded Species |
Antigen Retrieval |
|
WB |
0.1-0.5μg/ml |
Hu, Rat |
Ms |
- |
IHC-P |
0.5-1μg/ml |
Hu, Rat |
Ms |
By Heat |