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Anti-Episialin, EMA Monoclonal 100ug

Price:
$215.00
SKU:
BI-MA1039-100UG
Availability:
Usually Ships within 24 hrs.
Quantity:

Anti-Episialin, EMA Monoclonal

Clone EMA-39
Size  100μg/vial
Form lyophilized
Ig type mouse IgG1
Immunogen Human milk fat globule membranes.
Application IHC-P; IHC-F
Cross Reactivity Human.
Reconstitution 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used.  
  The antibody concentration will be 100μg/ml.
Storage At -20˚C for one year. After reconstitution, at 4˚C for one month. 
             It can also be aliquotted and stored frozen at -20˚C for a longer time. 
  Avoid repeated freezing and thawing.
   

MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells.

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