Size | 100μg/vial |
Form | Lyophilized |
Ig type | Rabbit IgG |
Immunogen | A synthetic peptide corresponding to a sequence at the N-terminal of human CXCR4, different from the related rat and mouse sequences by two amino acids. |
Application | WB,IHC-P |
Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Storage | At -20˚C for one year. After reconstitution, at 4˚C for one month. |
It can also be aliquotted and stored frozen at -20˚C for a longer time. | |
Avoid repeated freezing and thawing. | |
CXCR4 is the receptor for the CXC chemokine SDF1 that has essential functions on embryo organogenesis, immunological functions and T lymphocyte trafficking. CXCR4 is the only SDF1 receptor identified so far. This suggests that CXCR4 expression is critical for the biological effects of SDF1. CXCR4 is a seven-transmembrane-spanning, G-protein-coupled receptor for the CXC chemokine PBSF/SDF-1, it functions as a co-receptor for T-cell-line tropic human immunodeficiency virus HIV-1. Tachibana et al. (1998) conclude that PBSF/SDF-1 and CXCR4 define a new signalling system for organ vascularization. |
Concentration |
Tested Species |
Concluded Species |
Antigen Retrieval |
|
WB |
0.1-0.5μg/ml |
Hu, Rat |
Ms |
- |
IHC-P |
0.5-1μg/ml |
Hu |
- |
By Heat |