Clone | CN-3 |
Size | 100μg/vial |
Form | lyophilized |
Ig type | mouse IgG1 |
Immunogen | Recombinant chicken plakoglobin. |
Application | WB; IHC-F;ICC |
Cross Reactivity | Human, rat, chicken. |
Reconstitution | 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used. |
The antibody concentration will be 100μg/ml. | |
Storage | At -20˚C for one year. After reconstitution, at 4˚C for one month. |
It can also be aliquotted and stored frozen at -20˚C for a longer time. | |
Avoid repeated freezing and thawing. | |
Junction Plakoglobin (JUP) ,also knows as catenin gamma, is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. It is a component of the cadherin-catenin complex, which is predominantly localized where actin filaments anchor in adherens junctions of epithelial cells. The human plakoglobin gene localizes on chromosome 17q21. Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. |