Clone | IMD-3 |
Size | 100μg/vial |
Form | lyophilized |
Ig type | mouse IgG2a |
Immunogen | Synthetic peptide corresponding to residues 408-439 of |
the human p62c-Myc protein. | |
Application | WB; IHC-P; ICC |
Cross Reactivity | Human. |
Reconstitution | 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, |
the antibody concentration will be 100μg/ml. | |
Storage | At -20˚C for one year. After reconstitution, at 4˚C for one month. |
It can also be aliquotted and stored frozen at -20˚C for a longer | |
time. Avoid repeated freezing and thawing. | |
C-Myc is an oncogene that functions both in the stimulation of cell proliferation and in apoptosis. c-Myc elicits its oncogenic activity by causing immortalization, and to a lesser extent the transformation of cells, in addition to several other mechanisms. The c-MYC proto-oncogene encodes a transcription factor that is critical for cell growth and proliferation. It is one of the genes frequently altered in cancer cells in which it exhibits constitutive activity. Downregulation of c-Myc is critical for 2-Methoxyestradiol (2ME2)-induced oxidative stress and apoptosis in AML cells. And its up-regulation is important for promoting lymphocyte cell division, and demonstrating that GFP-c-Myc expression is a marker of proliferating lymphocytes in vivo.. |