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Anti-Arresten/COL4A1 Polyclonal
| Size | 100μg/vial |
| Form | Lyophilized |
| Ig type | Rabbit IgG |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminal of human Arresten, identical to the related rat and mouse sequence. |
| Application | WB |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Storage | At -20˚C for one year. After reconstitution, at 4˚C for one month. |
| It can also be aliquotted and stored frozen at -20˚C for a longer time. | |
| Avoid repeated freezing and thawing. | |
|
Arresten , also known as COL4A1 (Collagen type IV, alpha-1). Type IV procollagen contains 2 distinct chains. The collagen IV molecule is a heterotrimer of 2 alpha-1 chains and 1 alpha-2 chain .The COL4A1 gene is mapped to chromosome 13 and it is expressed in human donor corneas. Human arresten binds to alpha-1/beta-1 integrin and inhibits migration, proliferation, and tube formation by endothelial cells. Arresten elicited significant antiangiogenic effects and tumor growth inhibition in vitro but failed to do the same in alpha-1 integrin knockout mice. |
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|
Concentration |
Tested Species |
Concluded Species |
Antigen Retrieval |
|
|
WB |
0.1-0.5μg/ml |
Hu, Rat |
Ms |
- |
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