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Anti-Arresten/COL4A1 Polyclonal 100ug

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Anti-Arresten/COL4A1 Polyclonal

Size  100μg/vial
Form Lyophilized
Ig type Rabbit IgG
Immunogen A synthetic peptide corresponding to a sequence at the C-terminal of human Arresten, identical to the related rat and mouse sequence.
Application WB
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Storage At -20˚C for one year. After reconstitution, at 4˚C for one month. 
             It can also be aliquotted and stored frozen at -20˚C for a longer time. 
  Avoid repeated freezing and thawing.

Arresten , also known as COL4A1 (Collagen type IV, alpha-1). Type IV procollagen contains 2 distinct chains. The collagen IV molecule is a heterotrimer of 2 alpha-1 chains and 1 alpha-2 chain .The COL4A1 gene is mapped to chromosome 13 and it is expressed in human donor corneas. Human arresten binds to alpha-1/beta-1 integrin and inhibits migration, proliferation, and tube formation by endothelial cells. Arresten elicited significant antiangiogenic effects and tumor growth inhibition in vitro but failed to do the same in alpha-1 integrin knockout mice.



Tested Species

Concluded Species

Antigen Retrieval



Hu, Rat



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