EPO-α, Human

(Recombinant Human Erythropoietin-alpha, rHuEPO-α)

Purity: >98% by SDS-PAGE and HPLC analyses

Source: Escherichia coli

Erythropoietin (EPO) is a glycoprotein produced primarily by the kidney.

It is the principal factor in regulating erythropoiesis by stimulating the proliferation and differentiation of erythroid progenitor cells. The production of EPO by kidney cells is increased in response to hypoxia or anemia.

Recombinant EPO has been approved for the treatment of anemia associated with chronic renal failure as well as for anemia of AZT (azidothymidine) treated AIDS patients.

rHuEPO-α General Information
Amino Acid Sequence (166 aa):
APPRLICDSR VLERYLLEAK EAENITTGCA EHCSLNENIT VPDTKVNFYA WKRMEVGQQA VEVWQGLALL SEAVLRGQAL LVNSSQPWEP LQLHVDKAVS GLRSLTTLLR ALGAQKEAIS PPDAASAAPL RTITADTFRK LFRVYSNFLR GKLKLYTGEA CRTGDR

Reconstitution:
The sample should be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Reconstituted solutions are stable for up to one week at 2-8°C. Stock solutions should be aliquoted and stored at -80°C. Further dilutions should be made in appropriate buffered solutions.

Storage:
The lyophilized sample is stable at 2-8°C, but should be kept desiccated at -20°C for long term storage. The reconstituted sample can be apportioned into working aliquots and stored at -80°C for maximal stability. Avoid repeated freeze/thaw cycles.

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