CKS2, Human

(CDC28, CKSHS2, CKS2, CDC28 Protein Kinase 2.)

CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is necessary for their biological function. The CKS2 mRNA is expressed in various patterns through the cell cycle in HeLa cells, which shows spcific role for the encoded protein. CKS2 (CDC28) Protein kinase 2 binds to the catalytic subunit of cyclin-dependent kinases and has thus in involved in cell cycle regulation. CKS2 is required for the first metaphase/anaphase transition during the meiosis. An increase in expression of CKS2 protects the cells from apoptosis. CKS2 is essential during early embryogenesis and cell cycle progression in somatic cells.

CKS2 Human Recombinant fused to T7-Tag produced in E.Coli is a single, non- glycosylated polypeptide chain containing 94 amino acids and having a molecular mass of 11 kDa.

Purity: Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Source: Escherichia Coli.

Physical Appearance: Sterile Filtered colorless solution.

Formulation: The CKS2 protein solution contains 20mM Tris-HCl pH-7.5 and 20% glycerol.

CKS2 General Information

Amino acid sequence:
MASMTGGQQM GRGSHMAHKQ IYYSDKYFDE HYEYRHVMLP RELSKQVPKT HLMSEEEWRRLGVQQSLGWV HYMIHEPEPH ILLFRRPLPK DQQ.

Storage:
CDC28 although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

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