(6-{2-[4-(2,4-Dichloro-phenyl)-5-(4-methyl-1H-imidazol- 2-yl)-pyrimidin-2-ylamino]-ethylamino}-nicotinonitrile)
Purity > 99.0%
CAS Number: | 252917-06-9 |
Chemical Formula: | C22H18Cl2N8 |
Molecular Weight: | 465.34 g/mol |
CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively.
Solubility: Soluble in DMSO at 25 mg/mL with warming; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 20-40 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Storage: Store at or below -20 ºC.