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Bleomycin Sulfate
(Blenoxane, Bleo, Blexane)
USP Grade, 1.5-2.0 units/mg
| CAS Number: | 9041-93-4 |
| Molecular Formula: | C55H84N17O21S3 H2SO4 |
| Molecular Weight: | 1513.63 g/mol |
The sulfates of bleomycin are a mixture of basic antineoplastic antibiotics produced by glycopeptide Streptomyces verticullus. Bleomycin comprises a mixture of two components: bleomycin A2 and bleomycin B2. The approximate composition of A2:B2 is 2:1, but can vary greatly depending on the lot tested.
Bleomycin sulfate is a water soluble anticancer chemotherapeutic agent commonly used to treat Hodgkin’s lymphoma.
The mehanism of action of bleomycin is to bind to DNA and cause strand scissions. The exact mechanism of this breakage is not completely understood. Currently, it is thought that a chelating metal ions to decrease enzyme activity and stability. This effect is believed to cause enzymes to react with oxygen producing free radicals which create single stranded breaks in deoxyribose sugar.
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Bleomycin Sulfate Specifications:
| Appearance: | White or off-white crystalline powder |
| Solubilty: | 20mg/ml Water |
| Water Content (Karl Fisher): | Loss on drying: 6.0% |
| pH: | 4.5-6.0 |
| Melting Point: | 200-204 °C |
| Storage: | 2-8 °C |
Comparable Items:
| Selleck Chemicals | S1214-10MG |
| Selleck Chemicals | S1214-5G |
| Selleck Chemicals | S1214-10G |
| Selleck Chemicals | S1214-1G |
| Selleck Chemicals | S1214-50MG |
| US Pharmacopeia | 1076308 |
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