(NDSB-195; Dimethylethylammonium propane sulfonate; Non-detergent sulfobetaines 195)
Purity > 99.0 %
NDSB 195 is a zwitterionic compound that is used in protein crystallization and refolding. NDSB 195 is able to prevent protein aggregation and facilitate the renaturation either chemically and thermally denatured proteins. The applications are wide ranging in protein biochemistry useful to enhance extraction, solubilization and crystallization. NDSB is very soluble in water (greater than 2.0 molar) and do not alter significantly the pH or viscosity of biological buffers.
NDSB 195 does not show absorbance at 280 nm which is convenient for measuring protein concentration. In addition, enzymes have been shown to remain active in the presence of this reagent and can easily be removed by dialysis.
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