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ZSTK474 25mg

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(TCMDC-137004; 2-(Difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole)

Purity > 99.0%

 CAS Number:   475110-96-4
 Chemical Formula:   C19H21F2N7O2
 Molecular Weight:   417.41 g/mol


ZSTK474, a novel s-triazine derivative, binds to the ATP-binding site of Class I phosphatidylinositol 3-kinases (PI3K) and inhibits PI3K activity. ZSTK474 has strong antitumor activities against human cancer xenografts (A549, PC-3 and WiDr) when administered orally to mice.

Solubility: Soluble in DMSO at 20 mg/mL; soluble in ethanol at 2.5 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-5 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.

Storage: Store at or below -20 ºC. 

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