Urokinase, Human

(Urokinase, Abbokinase, Urokinase-type Plasminogen Activator,uPA, EC 3.4.21.73, UK.)

Urokinase (UK) is a serine protease, which is one of biological plasminogen activators. It is involved in a number of biological functions including fibrinolysis, embryogenesis, cell migration, tissue remodeling, ovulation, and wound healing. It can be obtained from human urine or kidney cell culture.

Urokinase is a two-chain glycoprotein containing 411 amino acids with 12 disulfide bonds. Its molecular weight is 54,000 Dalton.

Purity: Greater than 92.0% as determined by SDS-PAGE.

Source: Human urine.

Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation: The Urokinase was lyophilized from a concentrated (1mg/ml) solution containing phosphate buffer.

Urokinase General Information

Storage:
Lyophilized Urokinase although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Urokinase should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.

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