IL 28A Human, HEK

(Interleukin-28A, IL-28A, IFN-Lambda 2, Interferon-Lambda 2, Cytokine ZCYTO20, IL28A, IFNL2, ZCYTO20.)

IL-28A is distantly related to type I interferons and the IL-10 family. Expression of IL-28A is induced by viral infection which interacts with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha. IL-28A exhibits common features with type I IFNs such as antiviral activity, antiproliferative activity and in vivo antitumour activity. IL-28A acts similarly to IFNs, but is less effective generally and has activity in a more limited range of cell lines. IFN-ambda 1, IFN-lambda 2 and IFN-lambda 3 are closely positioned genes on human chromosome 19. IL-28A induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-gamma-independent manner. IL-28A is able to generate tolerogenic DCs, an activity that could thwart IFN-beta functions. IL-28A produced in response to viral infection, activates both monocytes and macrophages producing a restricted panel of cytokines and therefore is an important factor in activating innate immune responses at the site of viral infection.

Interleukin-28A Human Recombinant produced in HEK cells is a non-glycosylated monomer, having a total molecular weight of 24kDa. The IL28A is purified by proprietary chromatographic techniques.

Purity: Greater than 95% as obsereved by SDS-PAGE.

Source: HEK.

Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation: The IL28A was lyophilized from 1mg/ml in 1xPBS.

IL 28A General Information

Storage:
Lyophilized IL-28A although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL28A should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

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