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Anti-Phospholamban Polyclonal 100ug

Price:
$215.00
SKU:
BI-PA1309-100UG
Availability:
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Anti-Phospholamban Polyclonal

Size  100μg/vial
Form Lyophilized
Ig type Rabbit IgG
Immunogen A synthetic peptide corresponding to a sequence at the N-terminal of human Phospholamban, identical to the related rat and mouse sequences.
Application WB
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Storage At -20˚C for one year. After reconstitution, at 4˚C for one month. 
             It can also be aliquotted and stored frozen at -20˚C for a longer time. 
  Avoid repeated freezing and thawing.

Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2+ pump in cardiac muscle and skeletal muscle cells. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. Phospholamban is also expressed in slow-twitch skeletal muscle and some smooth muscle cells. McTiernan et al. (1999) observed that human ventricle and quadriceps displayed high levels of phospholamban transcripts and proteins, with markedly lower expression observed in smooth muscles, while the right atrium also expressed low levels of phospholamban. The structure of the human phospholamban gene closely resembles that reported for chicken, rabbit, rat, and mouse. Comparison of the human to other mammalian phospholamban genes indicated a marked conservation of sequence for at least 217 bp upstream of the transcription start site.


 

Concentration

Tested Species

Concluded Species

Antigen Retrieval

WB

0.1-0.5μg/ml

Rat

Hu, Ms

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