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ADH5, Human

Price:
$93.00
SKU:
PS-ENZ-595-5UG
Quantity:

ADH5, Human

(Alcohol dehydrogenase 5 (class III) chi polypeptide; Alcohol dehydrogenase class chi chain; Glutathione-dependent formaldehyde dehydrogenase; S-(hydroxymethyl) glutathione dehydrogenase; FDH; ADHX; ADH-3; FALDH; GSH-FDH; GSNOR; EC 1.1.1.1; EC 1.1.1.284)

ADH5 belongs to the alcohol dehydrogenase family which metabolizes a large selection of substrates, such as retinol, ethanol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. ADH5 has practically no activity for ethanol oxidation, but displays high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between glutathione and formaldehyde. ADH5 enzyme is a key factor of cellular metabolism for the removal of formaldehyde, a powerful aggravating and alerting mediator which causes pharyngitis, lacrymation, rhinitis and contact dermatitis.

ADH5 Recombinant produced in E. coli is a single polypeptide chain containing 398 amino acids (1-374) and having a molecular mass of 42.3kDa. ADH5 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Purity > 90% as determined by SDS-PAGE.

Source: E. coli.

Physical Appearance: Sterile Filtered colorless solution.

Formulation: The ADH5 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl, 1mM DTT and 20% glycerol.

ADH5 General Information

Amino Acid Sequence:
MGSSHHHHHH SSGLVPRGSH MGSHMANEVI KCKAAVAWEA GKPLSIEEIE VAPPKAHEVR IKIIATAVCH TDAYTLSGAD PEGCFPVILG HEGAGIVESV GEGVTKLKAG DTVIPLYIPQ CGECKFCLNP KTNLCQKIRV TQGKGLMPDG TSRFTCKGKT ILHYMGTSTF SEYTVVADIS VAKIDPLAPL DKVCLLGCGI STGYGAAVNT AKLEPGSVCA VFGLGGVGLA VIMGCKVAGA SRIIGVDINK DKFARAKEFG ATECINPQDF SKPIQEVLIE MTDGGVDYSF ECIGNVKVMR AALEACHKGW GVSVVVGVAA SGEEIATRPF QLVTGRTWKG TAFGGWKSVE SVPKLVSEYM SKKIKVDEFV THNLSFDEIN KAFELMHSGK SIRTVVKI

Storage:
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

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Celebrity Endorsements

Vasiliou and Nebert, Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family. Human Genomics 2005, 2:138-143 doi:10.1186/1479-7364-2-2-138

Östberga, et. al. Analysis of mammalian alcohol dehydrogenase 5 (ADH5): Characterisation of rat ADH5 with comparisons to the corresponding human variant. Chemico-Biological Interactions Volume 202, Issues 1–3, 25 February 2013, Pages 97–103.

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