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ABHD10, Human

Price:
$93.00
SKU:
PS-ENZ-612-2UG
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ABHD10, Human

(Abhydrolase domain containing 10 mitochondrial2; FLJ11342; EC 3.4.-.-.; Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Uniprot AAH14516; Entrez 55347)

Abhydrolase domain-containing protein 10 (ABHD10) is a member of the AB hydrolase superfamily. ADHD10 contains a alpha/beta hydrolase fold catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate.1 ABHD10 catalyzes the following conversion Mycophenolic acid O-acyl-glucuronide + H2O = mycophenolate + D-glucuronate.1

ABHD10 Human Recombinant produced in E. coli is a single polypeptide chain containing 279 amino acids (53-306) and having a molecular mass of 30.9kDa. ABHD10 is fused to a 25 amino acid His-tag at N-terminus and purified by proprietary chromatographic techniques.

Purity: Greater than 90% as determined by SDS-PAGE.

Source: E.coli.

Physical Appearance: Sterile Filtered colorless solution.

Formulation: The ABHD10 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 100mM NaCl and 20% glycerol.

ABHD10 General Information

Amino Acid Sequence:
MGSSHHHHHH SSGLVPRGSH MGSHMTSLSF LNRPDLPNLA YKKLKGKSPG IIFIPGYLSY MNGTKALAIE EFCKSLGHAC IRFDYSGVGS SDGNSEESTL GKWRKDVLSI IDDLADGPQI LVGSSLGGWL MLHAAIARPE KVVALIGVAT AADTLVTKFN QLPVELKKEV EMKGVWSMPS KYSEEGVYNV QYSFIKEAEH HCLLHSPIPV NCPIRLLHGM KDDIVPWHTS MQVADRVLST DVDVILRKHS DHRMREKADI QLLVYTIDDL IDKLSTIVN

Storage:
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles

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Celebrity Endorsements

1) Iwamura, et. al. Human alpha/beta hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver. J. Biol. Chem. 287:9240-9249 (2012)

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