Cefoperazone sodium salt

(Cefobid sodium salt)

Purity > 90.0%

Appearance: Faint beige powder

Store: 2-8 °C

Description

Cefoperazone sodium is a third generation cephalosporin antibiotic.  Cefoperazone sodium is freely soluble in aqueous solution (50 mg/mL).

Mechanism

Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Cefoperazone however, is largely resistant to β-lactamases produced by resistant cells.

Spectrum

Cefoperazone is primarily limited to gram negative bacteria namely Pseudomonas aeruginosa.

Microbiology Applications

Cefoperazone is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

• Pseudomonas aeruginosa 0.5 µg/mL – 64 µg/mL
• Haemophilus influenzae 0.06 µg/mL – 2 µg/mL

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