Bicine is a zwitterionic and often used as buffer to improve protein crystallization as well as other biochemical applications.
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Celebrity Endorsements
Cooper, D.R., et. al. (2007) Protein crystallization by surface entropy reduction: optimization of the SER strategy, Acta Crystallographica Section D, Vol. 63, 636-645.
Sirajuddin, M., et. al. (2007) Structural insight into filament formation by mammalian septins, Nature, 311-315.
Lohkamp, B., et. al. (2008) A mixture of fortunes: the curious determination of the structure of Escherichia coli BL21 Gab protein, Acta Crystallographica Section D, Vol. 64, 407-415.