Purity > 90.0%
Azlocillin is a semi-synthetic antibiotic derived from ampicillin and possesses a broader spectrum than carboxy penicillins. It has a strong in vitro potency and works by inhibiting the last stages of cell membrane construction.
β-Lactam antibiotics work by breaking up the peptidoglycan links in cell walls of non-resistant bacteria and triggers the release of hydrolases and autolysins which further break down the cell wall. In contrast to most cephalosporins, Azolocillin exhibits activity against enterococci.
Azlocillin functions by inhibiting the formation of peptidoglycan cross-links in the bacterial cell wall. The β-lactam moiety (functional group) of penicillin binds to the enzyme (DD-transpeptidase) that links the peptidoglycan molecules in bacteria, which weakens the cell wall of the bacterium. In addition, the build-up of peptidoglycan precursors triggers the activation of bacterial cell wall hydrolases and autolysins, which further digest the bacteria's existing peptidoglycan.
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