Anidulafungin inhibits glucan synthase, an enzyme important in the formation of β (1,3)-D-glucan, a major fungal cell wall component. Glucan synthase is not present in mammalian cells and therefore is an attractive target for antifungal activity.
Anidulafungin or Eraxis (Ecalta in Europe) is an antifungal drug. It was previously known as LY303366. There is preliminary evidence it has a similar safety profile to caspofungin. It has proven efficacy against oesophageal candidiasis, but its main use will probably be in invasive Candida infection; it will probably also have application in treating invasive Aspergillus infection. It is a member of the class of antifungal drugs known as the echinocandins; its mechanism of action is by inhibition of (1→3)β-D-glucan synthase, which is an important component of the fungal cell wall.
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