AEE-788

(AEE788; 6-{4-[(4-Ethyl-1-piperazinyl)methyl]phenyl}-N-[(1R)-1-phenylethyl]-1H-pyrrolo[2,3-d]pyrimidin-4-amine)

Purity > 99.0 %

AEE-788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE-788 inhibits phosphorylation of EGFR, HER2, and VEGF2, resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis. AEE-788 is in clinical trials.

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